The significance of the latter phenomenon is still unknown. Found inside – Page 162Sinus histiocytosis (SH) is a common, non-specific reaction that is ... Its prognostic significance (a marker of immune response) in this setting has been ... 1 This disorder is documented in all age groups, but adolescents are noted to be mostaffected. Other histiocytosis disorders, such as sinus hyperplasia and sinus histiocytosis with sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease, must be differentiated from viral, bacterial, acid-fast bacterial, and parasitic infections. 6.12).Pulmonary hilar lymph nodes in heavy smokers and elderly individuals contain a large number of sinus histiocytes with carbon pigments. Pulsoni A, et al. Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare and benign cause of lymphadenopathy and was first described in 1969. A case report. Found inside – Page 73The biologic significance of lymph node structure in breast cancer patients was ... sinus histiocytosis ( SH ) , appeared to be prognostically significant . Asai A, , Matsutani M, & Kohno T, et al: Leptomeningeal and orbital benign lymphophagocytic histiocytosis. These observations agree . Found inside – Page 1616The ophthalmologic manifestations of sinus histiocytosis with massive ... Immunologic abnormalities and their significance in sinus histiocytosis with ... Kitai R, et al. The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. Hum Pathol 20:711–715, 1989, McAlister WH, , Herman T, & Dehner LP: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Sinus . Carey MP, Case CP: Sinus histiocytosis with massive lymphadenopathy presenting as a meningioma. This group of disorders includes H syndrome, pigmented hypertrichosis with insulin-dependent diabetes mellitus (PHID), Faisalabad histiocytosis, and familial Rosai-Dorfman disease (also known as familial sinus histiocytosis with massive lymphadenopathy or . There are several types of histiocytosis, so try looking them up, and going by your symptoms. J Neurosurg 69:610–612, 1988, Bhattacharjee MB, , Wroe SJ, & Harding BN, et al: Sinus histiocytosis with massive lymphadenopathy — isolated suprasellar involvement. Sinus histiocytosis with massive lymphadenopathy--a review of seven cases. For example, sinus histiocytosis is a normal finding in mesenteric lymph nodes and the macrophages may contain endogenous pigment (hemosiderin, lipofuscin) or exogenous pigments reflecting antigen uptake from the digestive tract. Foucar E, Rosai J, Dorfman RF, et al. Leptomeningeal and orbital benign lymphophagocytic histiocytosis. Inflammatory meningeal masses of unexplained origin. Case report. Am J Clin Pathol 1984;82:515-25. The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues. * Emphasizes the immunophenotypic features, cytogenetic studies, and diagnostic ... significance of the degree of nuclear differen- tiation of the primary tumor (nuclear grade).4. Several cases of this disease involving the central nervous system are reviewed. The presence of SHML in these patients did not impact clinical decisions, and there was no evidence of SHML elsewhere. Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a disorder of unknown cause. Dolman PJ, Harris GJ, Weiland LH: Sinus histiocytosis involving the lacrimal sac and duct. Foucar E, Rosai J, Dorfman RF: The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. A predominance of sinuses distinguishes the histological pattern of sinus histiocytosis, which can occur in isolation or together with lymphocyte predominance and . Histiocytes & special histiocytes: Histiocytes: +/-Melanin pigment key feature (if present). Cancer 38:1614–1618, 1976 Kessler E, Srulijes C, Toledo E, et al: Sinus histiocytosis with massive lymphadenopathy and spinal epidural involvement. Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a disorder of unknown cause. "Histiocytosis, Sinus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Immunohistochemical characterization of the histiocytes in sinus histiocytosis with massive lymphadenopathy: analysis of an extranodal case. By Rodney T. Miller, M.D., Director of Immunohistochemistry From time to time, diagnostic pathologists encounter lymph nodes that contain a prominent population of histiocytes. Posttrauma to the draining sites Renal diseases: malignant hypertension, chronic glomerulonephritis, pyelonephritis The main histopathological features were a massive enlargement of the lymph node . Komp DM. This group of disorders includes H syndrome, pigmented hypertrichosis with insulin-dependent diabetes mellitus (PHID), Faisalabad histiocytosis, and familial Rosai-Dorfman disease (also known as sinus . In a separate review of axillary nodes from Japanese autopsy cases sinus histiocytosis was absent, suggesting that this finding in Japanese breast cancer cases was related to presence of the disease. Found insideOccasionally, sinus histiocytes are found to contain spindle shaped orovoidbrown ... toas 'Hamazaki Wesenberg' bodies 2 and are of unknown significance, ... Found inside – Page 52A study of two comparable groups fails to reveal any significant differences in ... Sinus histiocytosis Due mainly to the efforts of Black ( Black et al . The SHML in each case was present as a small focus, less than 1 cm. A correlation was possible between grading, staging, extent of lymph node involvement, and survival. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Found insideA reference for tackling diagnostic dilemmas that pathologists and clinicians encounter when assessing pediatric head and neck disease. Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review. Lipid-laden macrophages. Sinus histiocytosis with massive lymphadenopathy (SHML) was initially recognized by Destombes1 in 1965. Clin. It is important to distinguish SHML from other causes of histiocytosis because of the different treatment modalities. 1 ⇓ ⇓-4 While reports differ in terminology, there are generally 2 categories of SBO: typical and atypical. © Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). Pediatr Radiol 20:425–432, 1990 McAlister WH, Herman T, Dehner LP: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Hematology. 11, 15~16, 19 In 1963, Cutler, Black, and Gold- enberg examined a large breast cancer series (777 cases) and analyzed the relationship of patient survival to sinus histiocytosis and nu- clear grade, taking into account the effect of July 1992 - September 1993. PMC August 1986 - June 1992. Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy. Found inside – Page 1842Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy . Am J Clin Pathol 1984 : 92 : 515-525 . 23. Komp DM . ses Any of several diseases characterized by the abnormal proliferation of histiocytes in the tissues or organs. Am J Clin Pathol 82: 515 - 525, 1984 Foucar E, Rosai J, Dorfman RF, et al: Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy. Eosinophils. Am J Clin Pathol 82 . Contributed by Patricia Tsang, M.D., M.B.A. Sinus histiocytosis with massive lymphadenopathy, Ingestion or phagocytosis of red blood cells by macrophages / sinus histiocytes, Present in most axilla lymph nodes to some extent, marked after breast biopsy (, May also be associated with lymphoproliferative disorders, Reactive or due to trauma to the draining sites, Common in lymph nodes after trauma to draining sites, Renal diseases: malignant hypertension, chronic glomerulonephritis, pyelonephritis, Autoimmune and other immunopathologic conditions, Can be seen in lymph nodes with no apparent etiology, Brown discoloration of extensive hemosiderosis. Definition / general. Sinus histiocytosis with massive lymphadenopathy definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Foucar E, Rosai J, Dorfman RF, et al: The neurologic manifestations of sinus histiocytosis with massive lymphadenopathy. Medline ISI, Google Scholar. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathologic entity. Occasionally and confusingly, the term "histiocytosis" is sometimes used to refer to individual diseases. 5. Cancer 38:1614–1618, 1976, Lopez P, & Estes ML: Immunohistochemical characterization of the histiocytes in sinus histiocytosis with massive lymphadenopathy: analysis of an extranodal case. Rosai-Dorfman disease (RDD), otherwise known as sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and benign histiocytic proliferative disorder of unknown aetiology. Arch Pathol Lab Med 100:606–608, 1976 Ramos CV: Widespread bone involvement in sinus histiocytosis. Reactive lymph nodes are a sign that your lymphatic system is working hard to protect you. These infections may produce signs, symptoms, and hematologic findings similar to . Neurology 32:365–371, 1982 Foucar E, Rosai J, Dorfman RF, et al: The neurologic manifestations of sinus histiocytosis with massive lymphadenopathy. An ultrastructural and immunological study. Pettinato G, Manivel JC, d'Amore ES, Petrella G. Hum Pathol. Brain: Histiocytosis in the brain may cause a variety of symptoms. Found inside – Page 226... e.g. sinusoidal lobular carcinoma cells vs. sinus histiocytosis. The significance of nodal micrometastases (≤2mm: pN1mi) remains uncertain, ... Having had a number of such cases referred to our laboratory for immunostaining purposes, I thought it might be of interest to readers to briefly review the common differential diagnostic possibilities to keep in Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy or sometimes as Destombes-Rosai-Dorfman disease, is a rare disorder of unknown cause that is characterized by abundant histiocytes in the lymph nodes or other locations throughout the body. Cancer 42:77–80, 1978 Haas RJ, Helmig MSE, Prechtel K: Sinus histiocytosis with massive lymphadenopathy and paraparesis: remission with chemotherapy. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Prognosis. their significance in sinus histiocytosis with massive lymphadenopathy. Axilla Other lymph node groups Etiology. Found insidefavorable cases, isassociated with sinus histiocytosis and lymphoproliferative reaction ... from sinus histiocytosis and seems to have another significance. The majority of patients do not require treatment, demonstrating spontaneous resolution or stable disease. Occurrence in identical twins with retroperitoneal disease. Sinus histiocytosis with massive lymphadenopathy. Arch Pathol 87:63–70, 1969 Rosai J, Dorfman RF: Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathologic entity. Hum Pathol 20:711–715, 1989 Lopez P, Estes ML: Immunohistochemical characterization of the histiocytes in sinus histiocytosis with massive lymphadenopathy: analysis of an extranodal case. In spite of the absence of lymphadenopathy, the authors cautiously suggest the diagnosis sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai-Dorfman disease), based primarily on the biopsy finding of a certain . Maric I, Pittaluga S, Dale JK, Niemela JE, Delsol G, Diment J, Rosai J, Raffeld M, Puck JM, Straus SE, Jaffe ES. World J Clin Cases. Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare and benign source of lymphadenopathy of unknown aetiology, first described in 1969 by Rosai and Dorfman (cited by Moore et al. Rosai-Dorfman disease (RDD) also known as benign histiocytosis, or sinus histiocytosis with massive lymphadenopathy, is an extremely rare disorder which affects the lymph nodes in the neck. pattern, sinus histiocytosis (SH), and superior postoperative survival.7 The favorable prognos- tic significance of SH (Grade 2 or greater) was confirmed in subsequent studies by Hlack and his co-workers and by reports from other labora- torie~.'~~~'~~'~~'~~~~ However, some investigators failed to demonstrate such prognostic signifi- The malignant lymphomas included two cases of follicular lymphoma and two cases of Hodgkin's disease, nodular lymphocyte predominant type. No significant relationship could be established to anyone of the following criteria for which the literature reports varying prognostic values: Clinical staging of the disease, histological tumor type, grading, nuclear differentiation, round cell infiltration, perivenous infiltration, sinus histiocytosis, and lymph node reaction patterns . They may also cause the bones to fracture. Specialty. Arch Pathol Lab Med 109:867–870, 1985, Mirra SS, , Tindall SC, & Check IJ, et al: Inflammatory meningeal masses of unexplained origin. Sinus histiocytosis with massive lymphadenopathy and unusual extranodal manifestations. Found inside – Page 73The biologic significance of lymph node structure in breast cancer patients was ... sinus histiocytosis ( SH ) , appeared to be prognostically significant . However, when this finding becomes prominent, it can result in a somewhat alarming appearance. Abstract The term sinus histiocytosis with massive lymphadenopathy (SHML) was introduced by Rosai and Dorfman in 1969. Cancer 30:1174–1188, 1972 Rosai J, Dorfman RF: Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Thawerani H, Sanchez RL, Rosai J, et al: The cutaneous manifestations of sinus histiocytosis with massive lymphadenopathy. 426–431 Ghadially FN: diagnostic Electron Microscopy of Tumours, ed 2 field of neoplasms... Enlargement of the histiocytes in sinus histiocytosis with massive lymphadenopathy ( Rosai-Dorfman disease.!,... found insideO.T spectrum and significance of sinus histiocytosis in the lymph nodes in cancer inflammatory conditions berger,! ) sinus histiocytosis with massive lymphadenopathy ) of the histiocytes in sinus histiocytosis is an immune response that positive... Lymphadenopathy in the sinuses Erythrophagocytosis Hemosiderosis Epidemiology who underwent CT-guided percutaneous biopsy syndrome ) golden brown, granular. 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